Research Uncovers New Path to Treating Age-Related Hearing Loss
Looking for answers about how the brain works amid age-related hearing loss, Johns Hopkins Medicine researchers discovered that old mice were less capable than young mice of “turning off” certain actively firing brain cells in the midst of ambient noise. The result, they say, creates a “fuzzy” sound stage that makes it difficult for the brain to focus on one type of sound — such as spoken words — and filter out surrounding “noise.”
Scientists have long linked inevitable age-related hearing loss to hair cells in the inner ear that become damaged or destroyed over time.
Kanold and his team recorded the activity of 8,078 brain cells, or neurons, in the auditory cortex brain region of 12 old mice (16–24 months old) and 10 young mice (2–6 months old).
First, the researchers conditioned the mice to lick a water spout when they heard a tone. Then, the same exercise was performed while playing “white noise” in the background.
Without the ambient noise, the old mice licked the water spout just as well as the young mice when they heard the tone.
When the researchers introduced the white noise, overall, the old mice were worse at detecting the tone and licking the spout than the young mice.
Also, the young mice tended to lick the spout at the onset or the end of the tone. Older mice licked it at the start of the tone cue but also showed licking before the tone was presented, indicating that they thought a tone was present when there wasn’t one.
Next, to see how auditory neurons performed directly during such hearing tests, the researchers used a technique called two-photon imaging to peer into the auditory cortex in the mice. The technique uses fluorescence to identify and measure the activity of hundreds of neurons at the same time.
Under normal conditions, when brain circuitry worked correctly in the presence of ambient noise, some neuron activity increased when the mice heard the tone and, at the same time, other neurons became repressed, or turned off. In most of the old mice, however, the balance tipped to having mostly active neurons, and the neurons that were supposed to turn off when the tone was played in the presence of a noisy background failed to do so.
In addition, the researchers found that just before the tone cue, there was up to twice as much neuron activity in old mice than young mice, especially among males, causing the animals to lick the spout before the tone start.
A possible reason for that result, Kanold says, is that “in the old mice, the brain may be ‘firing’ or behaving as if a tone is present, when it’s not.”
The experiments with ambient noise also revealed that young mice experienced shifts in the ratio of active to inactive neurons, while older mice had more consistently active neurons overall. Thus, young mice could suppress the effects of ambient noise on neural activity while old mice could not, say the researchers.
“In older animals, ambient noise seems to make neuron activity more ‘fuzzy,’ disrupting the ability to distinguish individual sounds,” says Kanold.
On the upside, Kanold believes that because of the mammalian brain’s flexible learning potential, it can be “taught” to address the fuzziness in older animals, including humans.
“There may be ways to train the brain to focus on individual sound amid a cacophony of noise,” he says.
Kanold notes that more research is needed to precisely map the connection between the inability to shut off certain neurons and hearing loss amid ambient sound, including the brain circuits involved and how they change with age, as well as the potential differences between male and female animals.
Article originally appeared on SciTechDaily